Breaking Down Epigenetics: Sperm, Seminal Plasma, and Generational Impact

Epigenetics offers fascinating insights into how our genes are influenced by lifestyle and environmental factors. In this week’s episode of the Everything Epigenetics podcast, Dr. Raffaele Teperino and I delve into groundbreaking research on epigenetic inheritance and how reproductive fitness impacts long-term health. From the transfer of epigenetic material during conception to the role of paternal health in childhood obesity and diabetes risk, we discuss how these factors shape generational health outcomes.

You'll learn about:
• The role of epigenetics in reproductive fitness and how it goes beyond reproductive capacity.
• How sperm and eggs transfer more than just DNA, influencing offspring development through epigenetic material.
• The surprising impact of paternal health at conception on childhood obesity and metabolic disorders.
• The importance of lifestyle changes before conception to improve offspring health.
• Practical insights into integrating epigenetics into preventive medicine and public health.

Chapters:
00:00 Welcome & Introduction
01:09 Dr. Teperino’s journey into epigenetics and its link to complex diseases.
03:56 Understanding reproductive fitness and its connection to epigenetics.
08:33 The transfer of epigenetic material from sperm to oocyte.
17:01 The role of paternal health in shaping offspring health risks.
24:07 Longitudinal studies on early-life risks of obesity and diabetes.
37:44 The overlooked role of seminal plasma in reproductive health.
42:00 The future of epigenetics: Neurodevelopmental disorders and preventive health.
45:32 Closing thoughts and where to connect with Dr. Teperino.