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Everything Epigenetics
Don’t understand epigenetics? Don’t worry. There was a time when genetic analysis was hardly known or understood. Now, genetic analysis is performed by thousands of companies and your full genome can be decoded for less than $100. Epigenetics is how your behaviors change your outcome. Epigenetics gives us knowledge on how to change your life, and the ability to read biology to understand your current health status. You ARE in control. Your host, Hannah Went, is here to discuss the insights which can improve your life and health. She is here to bring you Everything Epigenetics, simplified.
Everything Epigenetics
The Power of Single-Cell Epigenetic Profiling with Alex Trapp
In this week’s episode of the Everything Epigenetics podcast, Hannah Went sits down with Alex Trapp, a computational biologist deeply involved in aging research. The two explore the cutting-edge development of single-cell epigenetic clocks and their potential applications in the field of longevity science. Alex shares his journey from experimental biology to computational approaches and discusses the significant implications of understanding aging at the single-cell level. He also provides insights into his work at Retro Biosciences, a company focused on extending healthy human lifespan through innovative therapies.
In this episode of Everything Epigenetics, you’ll learn about:
• The development and significance of single-cell epigenetic clocks
• Differences between bulk tissue and single-cell epigenetic sequencing methods
• Applications of single-cell aging clocks in understanding and potentially reversing aging
• Challenges and future directions in single-cell epigenetic research
• The exciting work being done at Retro Biosciences, including advancements in T-cell rejuvenation and plasma therapeutics
Chapters:
00:00 Introduction
03:15 Alex Trapp's journey in the aging research field
07:35 Overview of epigenetic clocks and single-cell approaches
17:38 Development and challenges of the single-cell aging clock
22:41 Applications and implications of single-cell clocks in aging research
35:57 Future directions in epigenetic research
42:55 Alex's work at Retro Biosciences and its potential impact
Review Alex’s Study: https://pubmed.ncbi.nlm.nih.gov/36211119/
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Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.